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Pregnancy and Neurofibromatosis (von Recklinghausen's Disease)

From the Department of Obstetrics and Gynecology. Saint Luke's Hospital, Cleveland. Ohio.

A case of neurofibromatosis adversely affected by pregnancy has been presented. The large neurofibromatosis lesions in this patient increased extensively during the latter part of pregnancy, mainly as the result of massive hemorrhage within the masses. Additionally, the patient developed partial paralysis of the lower extremities resulting in inability to walk. This was thought to be due either to the development of neurofibromatosis or to enlargement of a previously existing intraspinal small neurofibromatosis lesion. In view of exacerbation of von Recklinghausen's disease during pregnancy, as reported here and recorded by others, and its hereditary transmission (autosomal dominant gene), early termination of pregnancy and sterilization are recommended.