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Androgenic Function of a Granulosa Cell Tumor

From the Departments of Obstetrics and Gynecology and Pathology at the Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

Virilizing granulosa cell tumors are uncommon and have not been well studied hormonally. A hirsute woman with a cystic granulosa cell tumor of the ovary is presented. Plasma hormone levels obtained before and after surgery indicate testosterone production by the tumor with LH and FSH suppression. Plasma testosterone (T) and T-index returned to normal after tumor removal, and ovulation resumed.

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