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Obstetrics & Gynecology 1976;47:63-68
© 1976 by The American College of Obstetricians and Gynecologists
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Diagnostic Use of Maternal Serum Alpha- Fetoprotein Levels

FSUSAN COWCHOCK, MD and LAIRD G. JACKSON, MD

Abstract

Alpha-fetoprotein (AFP) levels in human maternal serum were elevated in 14 patients vthen measured by a radioimmunoassay. In X patients the elevated serum levels of AFP correlated with increased concentration of AFP in amiotic fluid and were diagnostic of fetal defects. The elevated AFP levels in the remaining 6 patients were shown to be the result of fetomaternal transfusion from either amniocentesis or natural causes. Serum samples drawn after amniocentesis through an anterior placenta may show false-positive elevations. The use of both maternal serum and amniotic fluid samples in pregnancies at high risk for neural tube defects can decrease the risk of diagnostic errors due to mistakes in gestational dating and may increase the diagnostic sensitivity of amniocentcsis






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Copyright © 1976 by the American College of Obstetricians and Gynecologists.