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Obstetrics & Gynecology 1976;47:46-49
© 1976 by The American College of Obstetricians and Gynecologists
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Failure of Triiodothyronine to Prevent Propylthiouracil-Induced Hypothyroidism and Goiter in Fetal Sheep

EDGAR O. HORGER, III, MD, FACOG, JAMES G. KENIMER, PhD, MIZUO AZUKIZAWA, MD, JEROME M. HERSHMAN, MD, P C KANSAL, MD and A B LEAMING

From the Departments of Obstetrics and Gynecology and Medicine, Medical University of South Carolina, Charleston, South Carolina and the Endocrinology Research Laboratory, Veterans Administration Wadsworth Hospital Center and Department of Medicine, University of California, Los Angeles, California

Abstract

Administration of propylthiouracil (PTU) to pregnant, third trimester sheep led to decreasing serum thyroxine and increasing serum thyroid-stimulating hormone in both mothers and fetuses. Hypothyroidism appeared more pronounced in the fetuses than in the ewes, and goiter formation was observed in all fetuses exposed to PTU. Concomitant administration of triiodothyronine failed to protect the fetuses from the effects of ITU.






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