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Obstetrics & Gynecology 1975;46:581-583
© 1975 by The American College of Obstetricians and Gynecologists
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Further Observations on the Nature of Pressor Responsivity to Angiotensin II in Human Pregnancy

F GARY CUNNINGHAM, MD. KAY COX and NORMAN F. GANT, MD, FACOG

From the Division of Maternal-Fetal Medicine of the Department of Obstetrics and Gynecology al The University of Texas Health Sciences Center, Southwestern Medical School at Dallas, Dallas, Texas

Abstract

The pressor dose of infused angiotensin II was determined before and after rapid volume expansion with 800 to 1075 ml of highhetnatocrit blood There was no remarkable change in sensitivity to infused angiotensin demonstrated except in two in stance in which transient volume overload developed. The data support the hypothesis that increased angiotensin sensitivity observed in patients with pregnancy-induced hypertension is the consequence of increased vascular responsivity.






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Copyright © 1975 by the American College of Obstetricians and Gynecologists.