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Obstetrics & Gynecology 1975;46:539-543
© 1975 by The American College of Obstetricians and Gynecologists
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Pituitary and Ovarian Response Patterns to Stimulation in the Postpartum and in Galactorrhea-Amenorrhea

The Role of Prolactin

E. del POZO, MD, L. VARGA, MD, K D SCHULZ, MD, H J KÜNZIG, MD, P. MARBACH, PhD, G LOPEZ del CAMPO, MD and U. EPPENBERGER, PhD

From the Departments or Experimental Therapeutics and Pharmacoloay, Sandoz Ltd, and Universitaets-Frauenklinik, Basil Switzerland; Kamonsspital Liestal, Switzerland and Untversitaets- Frauenklinik. Cologne. German Federal Republic

Abstract

In order to assess the action of prolactin on the puerperal pituitary-ovarian resistance to physiologic stimulation, a study was conducted in 27 women divided into three croups. Group 1:9 postpartum women who did not wish to breastfeed their infants and received 2.5 mg bromocriptin (CB 154) twice daily for 14 days starting immediately after delivery: Group II: 9 normally lactating mothers; and Group III: 9 women with hyperprolactinemia associated with amenorrhea. The three groups underwent stimulation with LHRH and Pergonal 500. Results indicate lack of prolactin dependence in the pituitary-ovarian resistance of the puerperium. The possible mechanisms involved in the anovulatory period of lactation arc discussed.






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Copyright © 1975 by the American College of Obstetricians and Gynecologists.