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Evaluation of Carcinoma of the Cervix Using ¹¹¹In-Bleomycin

From the Section of Gynecologic Oncology and Section of Nuclear Medicine at Los Angeles County/University of Southern California Medical Center. Los Angeles. California.

Abstract

Indium-111 attached to bleomycin is useful in the scintigraphic localization of a variety of tumors. Since it does not normally accumulate in bowel and feces, it is superior to other radiopharmaceuticals, such as gallium-67-citrate, in the demonstration of abnormalities in the abdomen and pelvis. Twenty-eight patients with known carcinoma of the cervix were studied with whole body ¹¹¹In-bleomycin scans. Two "false-positive" scans were produced by local inflammation. Six "false-negative" scans were attributed to small tumors escaping scintigraphic detection. In the remaining 20 patients, scan findings correlated well with site and extent of the tumor as determined by other means. ¹¹¹In-bleomycin scintiscanning may prove to be a highly useful adjunct in the evaluation of patients with carcinoma of the cervix.