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Obstetrics & Gynecology 1974;44:388-393
© 1974 by The American College of Obstetricians and Gynecologists
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Intrapartum Epidural Anesthesia

An Evaluation of Effects on Uterine Activity

RICHARD I. LOWENSOHN, MD, RICHARD H. PAUL, MD, FACOG, STEVEN FALES, BSEE, SZE-YA YEH, MD and EDWARD H. HON, MD, FACOG

From the Department of Obstetrics and Gynecology, LAC/USC Medical Center, Los Angeles, California

Abstract

A retrospective study was done of 65 lumbar segmental epidural injections in 54 patients in whom uterine activity was monitored before and after the injection of either lidocaine or propitocaine hydrochloride. All records were screened to eliminate known variables. A significant depression of uterine activity lasting 30 minutes was found after lidocaine injection. This drop did not correlate with blood pressure changes, parity, stage of labor, use of oxytocin, or addition of epinephrine in the injection. The second drug studied, propitocaine, showed much less effect on uterine activity. While this drug is not acceptable for routine use, the difference in action suggests that this method of analysis should be used to screen for other drugs with less uterine depression than lidocaine.






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Copyright © 1974 by the American College of Obstetricians and Gynecologists.