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In Vivo Endocrine Studies in Adrenal Rest Tumor of Ovary

From the Departments of Endocrinology and Obstetrics and Gynecology at the Medical College of Georgia, Augusta, Georgia

Abstract

Radioimmunoassay of several plasma steroids and gonadotropins and routine urinary steroid analyses were performed on a patient before, during, and after removal of an ovarian adrenal rest tumor. Follicle-stimulating hormone and luteinizing hormone were low, but testosterone, 5-dihydrotestosterone, progesterone, 17 OH-progesterone, and ⁴-androstenedione were markedly elevated prior to surgery. Urinary 17 ketosteroids were slightly elevated and did not decrease during treatment with dexamethasone although urinary 17 hydroxycorticosteroids, plasma cortisol, and plasma dehydroepiandrosterone did suppress. The elevated plasma steroids were significantly lowered after tumor excision, and the patient, once amenorrheic, now has normal, ovulatory menstrual cycles.