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MALIGNANT POTENTIAL OF THE DYSGENETIC GONAD Part I

From the Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
^* Part II will be presented in a later issue of this journal.

The karyotypes of patients with gonadal dysgenesis and gonadal malignancies are evaluated in a literature review for their clinical significance. Most patients were found to have a Y chromosomal component in their karyograms. The gonadoblastoma appears to be the most common associated gonadal malignancy and is often initially diagnosed as a dysgerminoma. Metastatic dysgerminomatous components and the association of embryonal carcinomas and choriocarcinomas reveal the extent of the malignant potential. The risk of malignancy in dysgenetic gonads of patients with a Y chromosomal component is estimated from a review of the experience of individual institutions to be 25%. The relation between karyotype, embryogenesis, carcinogenesis, and phenotype are discussed for the understanding of the clinical symptomatology.

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