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From the Departments of Obstetrics and Gynecology and Radiation Therapy, the State University of New York at Stony Brook, the Long Island Jewish Hospital Center, and The Jamaica Hospital.
Abstract
The gross and microscopic changes following different modes of therapy for 97 cases of Stage I and II carcinoma of the cervix were studied. Features frequently present in the radiotherapy patients were: narrowing or obliteration of the vagina, pelvic fibrosis, pain or discomfort on pelvic examination, and gross and microscopic changes in the vagina typical of radiation fibrosis; in addition, the vaginal cytology was not altered after estrogen stimulation. These features were less frequent in the surgical patients. Of all the organs in the body, the vagina is exposed to the heaviest doses of irradiation.
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