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Serial Estimations of Serum Unconjugated Estradiol-17ß in High-Risk Pregnancies

From the Department of Obstetrics and Gynecology, University of Singapore, Kandang Kerbau Hospital, Singapore 8, Republic of Singapore.

Abstract

Serum unconjugated estradiol-17ß (E₂) was measured by a rapid radioimmunoassay method using a specific antibody. Serial estimations of serum E₂ were performed in 10 pregnancies and 3 twin pregnancies complicated by hypertensive disorder of pregnancy, 2 cases of bad obstetric history, 8 cases of uncomplicated twin pregnancy, and 3 uncomplicated triplet pregnancies. Serum E₂ was also measured in 7 instances of intrauterine death. In 2 of the 10 patients with hypertensive disorder of pregnancy resulting in delivery of dysmature, growth-retarded babies, serial serum E₂ showed a falling trend, with two or more successive values below the standard deviation range for normal pregnancy. A similar pattern was obtained in a case of bad obstetric history resulting in neonatal death of a dysmature, growth-retarded infant. In all 3 cases, serum E₂ was below 10 ng/ml. In 6 cases of intrauterine death due to placental dysfunction, serum E₂ levels were low (between 0.375 and 6.46 ng/ml), while serum E₂ was normal in 1 case of intrauterine death not due to placental dysfunction. Serum E₂ was higher in uncomplicated twin and triplet pregnancies than in single pregnancies. The advantages and potential value of serum E₂ measurement as an index of placental function are discussed.

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