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Plasma Steroids in Hirsutism

From the Division of Reproductive Biology of the Department of Obstetrics and Gynecology, UCLA School of Medicine, Harbor General Hospital Campus, Torrance, California and the Division of Endocrinology, Department of Pathology and Medicine, Baylor University Medical Center, Dallas, Texas.

Abstract

Serum levels of testosterone (T), 5-dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), androstenedione (A), dehydropiandrosterone-sulfate (DHEA-S), 17-hydroxyprogesterone (17-P), androst-5-ene-3ß, 17ß-diol (⁵-diol), and cortisol (F) were measured in 17 hirsute patients. As a group, the hirsute patients showed significantly elevated levels of all steroids measured in comparison to nonhirsute subjects. As individuals, the hirsute patients showed an elevated serum 17-P level as the most consistent finding; elevation was present in 16 of the 17 patients. Eighty-two percent of the hirsute women had elevated T, DHT, and F. Serum levels of DHEA, DHEA-S, A, and ⁵-diol were elevated in about half of the patients.