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Effect of L-Dopa on Galactopoiesis and Gonadotropin Levels in the Inappropriate Lactation Syndrome

From the Departments of Endocrinology and Obstetrics and Gynecology A, The Municipal Governmental Medical Center, Tel-Aviv-Jaffa; The Department of Biodynamics, The Weizmann Institute of Science, Rehovot, Israel and the Institute of Medicine, Laboratory of Radioimmunology, University of Liege, Liege, Belgium.

Abstract

Ten oligomenorrheic or amenorrheic patients with the inappropriate lactation syndrome were observed during oral treatment with L-Dopa, using various therapeutic regimens. In 4 of 7 subjects, galactorrhea was effectively suppressed by chronic ingestion of L-Dopa. Cessation of treatment resulted in the resumption of lactation. In an addition patient a permanent inhibition of lactation was attained after 15 days of therapy. In the remaining 2 patients only partial suppression of galactorrhea was achieved during treatment. Short-term treatment had no effect on the galactorrhea. Six patients experienced normal ovulatory cycles during therapy. Of this group 2 patients became pregnant. These date suggest that L-Dopa therapy might be effective for suppression of abnormal lactation and might also be of potential use in subjects with anovulation due to hypothalamic disturbances.