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Obstetrics & Gynecology 1974;44:53-59
© 1974 by The American College of Obstetricians and Gynecologists
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Endocervical Changes With the Use of Synthetic Steroids

R. MINGEOT, MD and CL, FIEVEZ, MD

From the Department of Gynecology-Obstetrics. Clinique Saint-Michel, Brussels, and Laboratory of Pathology. Loverval. Belgium.

From the study of the biopsies of 106 endo-exocervical junctions, it appears that the endocervical epithelium undergoes important changes under the influence of synthetic estroprogestatives. When at their maximum, these changes are unequaled in any other circumstance, even during pregnancy. The frequency of metaplasia increases significantly under treatment. Adenomatoid hyperplasia was observed infrequently under treatment (2 of 106 cases). Further observations must be carried out to determine the significance of the reported histologic changes.






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Copyright © 1974 by the American College of Obstetricians and Gynecologists.