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Obstetrics & Gynecology 1974;44:35-41
© 1974 by The American College of Obstetricians and Gynecologists
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Hyperthecosis Syndrome

MARTIN FARBER, MD, FACOG., PHILIP ROGER DAOUST, MD and JOSEPH ROGERS, MD

From the Department of Obstetrics and Gynecology. Department of Pathology, and Department of Medicine. Tufts University School of Medicine and The New England Medical Center Hospital. Boston, Massachusetts.

Hyperthecosis syndrome must be included in the differential diagnosis of the mildly virilized female who demonstrates ovarian hyperresponsiveness (measured by plasma lestosterone) to intramuscular human chorionic gonadotropin. Ovarian biopsy, with the typical histologic finding of stromal theca cells at a considerable distance from the theca interna, is diagnostic and may be therapeutic. The necessity of separating this unusual syndrome from the spectrum of polycystic ovarian disease is based on the clinical observation that these masculinized anovulatory females do not respond to clomiphene citrate and only on occasion respond to ovarian wedge resection.






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Copyright © 1974 by the American College of Obstetricians and Gynecologists.