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Effect of Chorionic Gonadotropin

Serum Progesterone Values in the Luteal Phase Defects

From the Department of Gynecology and Obstetrics. The Johns Hopkins University School of Medicine. Baltimore. Maryland and the Department of Obstetrics and Gynecology. Duke University School of Medicine. Durham. North Carolina.

Patients with luteal phase defects diagnosed by timed endometrial biopsy were further evaluated with daily serum progesterone values obtained during control and and treatment cycles. Treatment consisted of administration of either intramuscular or local progesterone. or intramuscular human chorionic gonadotropin (HCG) during the luteal phase. The luteal defect was left to be satisfactorily corrected when the histologically dated endometrial biopsy was in agreement with dating from ovulation and to the next menses. Elevated serum progesterone values were observed in 6 of 8 patients treated with exogenous progesterone and in 1 of 2 patients treated with HCG. One patient demonstrated a poor response to HCG administration and required large doses for adequate progesterone output and correction of her endometrial defect.

This article has been cited by other articles:

				K. Sheehan, R. Casper, and S. Yen Luteal phase defects induced by an agonist of luteinizing hormone-releasing factor: a model for fertility control Science, January 8, 1982; 215(4529): 170 - 172. [Abstract] [PDF]