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Obstetrics & Gynecology 1974;44:135-141
© 1974 by The American College of Obstetricians and Gynecologists
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Plasma Hormone Profiles Following High-Dose Intraamniotic Prostaglandin F2{alpha}

IAN CRAFT, FRCS, MRCOG, ELIZABETH CARRIERE and EZAT YOUSSEFNEJADIAN, PhD

From the Institute of Obstetrics and Gynecology, Chelsea Hospital for Women, London, SW3.

Plasma progesterone, 17-hydroxyprogesterone, estrone, estradiol, and estriol were determined before and serially after the intraamniotic injection of prostaglandin F2A (75 mg) for induction of midtrimester abortion. A general decline in hormone concentrations preceded the mean time to abortion by several hours. The decreases in plasma progesterone and estriol were significant 3 hours after the injection procedure, indicating a definite effect on the fetoplacental unit.






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