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Typhoid Fever Complicating Pregnancy

Seven patients were diagnosed as having From the Department of Obstetries and Gynecology of the University of Miami School of Medicine. Miami, Florida.

Seven Patients were diagnosed as having typhoid lever complicating their pregnancy. At case were confirmed by blood cultures and stool cultures were positive in 4 women. Cervical and nine cultures were all negative. The presenting symptoms resembled a flu-like syndrome with fever. Chills, malaise. anoxia. and diarrhea being most common. The characteristic -rose-spot- skin rash was seen in 3 patients. The recognized -relative bradycardia" of typhoid lever during lebrile episodes was observed in both the mother and letus. All women were neated with ampicillin for 14 days and this resulied in the abatement of symptoms within 5 days. There were no re1apses and all cultures remained negative after therapy. Pregnancy did not seem to alter the course of the inlection One of the 7 pregnancies terminated in a spontaneous abortion. with extensive letal liver necrosis. All other infants were delivered mature, noninfected and normal. These results appeal to be an improvement over previous experiences with this disease.