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Relation of Type 2 Herpesvirus Antibodies to Cervical Neoplasia

US Department of Health, Education and Welfare, Public Health Service, Center for Disease Control, Bureau of Epidemiology, Atlanta, Georgia.

The relation between herpes simplex Type 2 (HSV-2) antibodies and cervical neoplasia was analyzed in a small subset of women who had been part of a cervical cytologic screening campaign in the Barbados, West Indies, since 1964. Fifty percent of the chosen sample were contacted during a door-to-door survey. A serologic specimen was drawn from each woman. The serum was separated, frozen, and returned to the United States for testing for type-specific herpesvirus antibodies by the complement fixation techntc. The relative risk that a woman with herpes HSV-2 antibody had cervical cancer was 10.4 (P < .025). This risk was not explained by differences in cases and controls with respect to age, total number of pregnancies, age at first pregnancy, or age at first coitus. There was no significant relation between prevalence of HSV-2 antibodies and cervical dysplasia. The question still unanswered is whether the herpetic infection precedes or follows the development of cervical cancer. A cohort study should be done to answer this question.