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Obstetrics & Gynecology 1974;43:769-779
© 1974 by The American College of Obstetricians and Gynecologists
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Fertility Control by Intrauterine Release of Progesterone

ANTONIO SCOMMEGNA, MD, FACOG, THERESITA AVILA, MD, MANUEL LUNA, MD, RAMAA RAO, MD and W. PAUL DMOWSKI, MD, PhD

From the Section of Gynecic Endocrinology of the Department of Obstetrics and Gynecology, Michael Reese Medical Center and the Pritzker School of Medicine, University of Chicago, Chicago, Illinois.
Send reprint requests to Antonio Scommegna, MD Dept of Obstetrics and Gynecology Michael Reese Medical Center Chicago, IL 60616

T-shaped intrauterine devices releasing about 128 µg of progesterone per day were inserted in 249 women for contraceptive purposes. After 6 months, the IUD's were replaced with new devices. More than 1600 woman-months of use were accumulated. No pregnancy was recorded with an active progesterone releasing system in place. Plasma hormonal assays and cervical mucus studies performed in selected patients were found to be normal, suggesting that the mechanism of progesterone IUD's is not connected with inhibition of ovulation or with alteration in cervical mucus. It is concluded that intrauterine progesterone in very small doses is an effective contraceptive. Its mechanism of action is probably related to the decidual changes induced in the endometrial receptor, rendering it unsuitable for implantation.






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Copyright © 1974 by the American College of Obstetricians and Gynecologists.