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Amniotic Fluid Assay as an Index for Gestational Age and Fetal Development in the Baboon

From the Department of Gynecology and Obstetrics, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma.
Address reprint requests to O. Ray Kling, PhD The University of Oklahoma Health Sciences Center PO Box 26901 Oklahoma City, OK 73190

The total lecithin/sphingomyelin ratio, creatinine concentration, OD at 450 nm, and lipid cell content were determined in baboon amniotic fluids from 90 through 176 days' gestation. The mean values for the L/S ratio and crcatinine increased with gestational age, showing a significant increase in concentration during late gestation. These data for mean L/S ratio, and also individual serial determinations, indicate that the baboon L/S ratio correlates with gestation, thus showing similarity to the data reported for the human. The bilirubin ( 450 nm) and presence of lipid cells in baboon fluid were found to follow the same patterns as those established for human gestation. These findings indicate the baboon is a representative subhuman primate model for studying human fetal development and maturation.