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Induction of Ovulation With Cisclomiphene and a Placebo

From the Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine and Pennsylvania Hospital, Philadelphia, Pennsylvania.
Address reprint requests to James F. Connaughton, MD Department of Obstetrics and Gynecology Pennsylvania Hospital Eighth and Spruce Streets Philadelphia, PA 19107

Cisclomiphene, one of the two isomers of clomiphene, has been previously used for induction of ovulation. This paper describes the use of cisclomiphene in 5-mg and 10-mg dose schedules, and compares its effectiveness to that of a placebo in a double-blind study. A significant observation was that patients receiving the placebo apparently responded with ovulation as frequently as those subjects given cisclomiphene. In this limited series, cisclomiphene does not appear to be more effective in ovulation induction or in pregnancy rate than clomiphene citrate. The importance of dose level is pointed out as well as the numerous factors that may be involved in successful use of clomiphene-like drugs.