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Distribution of Isozyme Patterns in Cervical Dysplasia

From the Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
Address reprint request to Rupi Prasad, PhD Department of Obstetrics and Gynecology Baylor College of Medicine 1200 Moursund Avenue Houston, TX 77025

Enzyme patterns of lactate dehydrogenase, malate dehydrogenase, and -esterase were studied in cells obtained by cervical scrapings. The starch gel electrophoretic study of enzymes was performed in 130 cervical smear samples from 110 women with cervical dysplasia and from 20 normal women. In most of the smear samples (either from normal or from dysplasia patients) lactate dehydrogenase activity was not detected. Wherever the activity of this enzyme was present, only some of the isozymic forms were detected. In only three of the samples studied were all five isozymic forms shown. The patterns of -esterase and malate dehydrogenase were variable in all the samples studied. Variations in malate dehydrogenase were present mainly in the smear samples of women with dysplasia and only in the supernatant type of the enzyme. The significance of variations in -esterase and malate dehydrogenase is not apparent at this time.