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From the Department of Pathology, Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Address reprint requests to Hector Tobon, MD Department of Pathology Magee-Womens Hospital Forbes A venue and Halket Street Pittsburgh, PA 15213
Eleven cases of primary malignant melanoma of the female genital tract, included in the Magee-Womens Hospital Tumor Registry from 1947 to 1972, were reviewed. Clinical and pathologic findings were compiled, and lesions were retrospectively staged and compared with studies in the literature. Five cases involved the vagina; 6 involved the vulva. The mean age was 62 years, and the most frequently reported symptoms were bleeding (72.7%) and a lump or mass (54.59%). Three patients showed metastases to regional lymph nodes at the time of original surgery, and 6 later developed metastases to the bladder, pelvis, lung, meninges, and/or nerve roots. The best survival rate was associated with radical surgery along with lymph node dissection. The prognosis for tumors in the vagina was worse than for those in the vulva, with a mean survival of 19.4 months and 36.6 months, respectively.
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