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Obstetrics & Gynecology 1974;43:640-644
© 1974 by The American College of Obstetricians and Gynecologists
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Mesonephric (Clear Cell) Carcinoma of the Vagina and Cervix

A Retrospective Analysis

KENNETH L. NOLLER, MD, DAVID G. DECKER, MD, MALCOLM B. DOCKERTY, MD, ANN P. LANIER, MD, REGINALD A. SMITH, MD, FACOG and RICHARD E. SYMMONDS, MD, FACOG

From the Mayo Clinic and Mayo Foundation, Rochester, Minnesota. Send reprint requests to Kenneth L. Noller, MD c/o Section of Publications Mayo Clinic Rochester, MN 55901

Cases of mesonephric (clear cell) adenocarcinoma of the vagina and cervix seen at the Mayo Clinic were reviewed. Ten such lesions, 2 vaginal and 8 cervical, occurred in patients horn subsequent to the first clinical use of stilbestrol (1939). Follow up disclosed that the mother had received synthetic estrogen therapy during pregnancy in 1 case of vaginal cancer and in 3 cases of cervical tumor. A definite increase in the number of mesonephric cancers has been noted in all age groups since 1960, although most of these cases are unrelated to maternal synthetic estrogen.






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