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Obstetrics & Gynecology 1974;43:592-594
© 1974 by The American College of Obstetricians and Gynecologists
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Amniotic Fluid Alpha-Fetoprotein in Anencephaly

AUBREY MILUNSKY, MBBCh, MRCP, DCH, ELLIOT ALPERT, MD and DAVID CHARLES, MD, FACOG

From the Departments of Pediatrics and Medicine, Harvard Medical School, Department of Obstetrics, Boston University School of Medicine and the Eunice Kennedy Shriver Center for Mental Retardation, the Gastrointestinal Unit, Massachusetts General Hospital, and the Division of Obstetrics and Gynecology, Boston City Hospital

Abstract

Markedly elevated amniotic fluid alpha-feloprotcin (AFP) levels were found in 9 cases of anencephaly, compared to 61 normal controls, 7 other fetal and 4 other obstetric abnormalities. Biochemical estimation of amniotic fluid AFP adds a new dimension to the early prenatal diagnosis of neural tube defects. The specificity and accuracy of amniolic fluid AFP testing must, however, still be established before routine use can be recommended.






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Copyright © 1974 by the American College of Obstetricians and Gynecologists.