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Obstetrics & Gynecology 1974;43:535-538
© 1974 by The American College of Obstetricians and Gynecologists
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Arrhenoblastoma Associated With Adrenal Androgenic Hyperfunction

DWIGHT P. CRUIKSHANK, MD, MICHAEL E. YANNONE, MD, FACOG and FREDERICK K. CHAPLER, MD, FACOG

From the Department of Obstetrics and Gynecology. University of Iowa Hospitals, Iowa City. Iowa

Abstract

A case is presented of a patient with secondary amenorrhea and viriltzalion with markedly elevated arinary 17-ketosteroids and plasma androgens. Differential adrenal and ovarian suppression indicated adrenal androgenic hyperfunction as well as a semi-autonomous ovarian source of androgen production. An arrhenoblastoma was removed, and the adrenal disorder responded to long-term dexamethasone suppression. This is an unusual case of two distinct audrogenic disorders, including partially supressiblc arrhenoblastoma, occurring in the same patient.






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Copyright © 1974 by the American College of Obstetricians and Gynecologists.