HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by LEDGER, W. J. Articles by FEKETY, F R. Search for Related Content PubMed PubMed Citation Articles by LEDGER, W. J. Articles by FEKETY, F R., JR

The Use of Parenteral Clindamycin in the Treatment of Obstetric-Gynecologic Patients With Severe Infections

A Comparison of a Clindamycin -Kanamycin Combination With Penicillin-Kanamycin

From the Departments of Obstetrics and Gynecology, Bioengineering, and Internal Medicine, the University of Michigan, Ann Arbor, Michigan

Abstract

Using a system of random selection in patients with severe obstetric—gynecologic infections. parenteral penicillia-kanamycin was given to 23 women and clindaniycin-kanamycin was given to 21. Therapeutic response to the two antibiotic regimens was similar; no significant differences were noted in either the posttreatment fever index or the numbers of women requiring other therapy. There was a failure of response to the penicillia-kanamycin regimen in those women with Bacteroides fragilis infection and to the clindamycin-kanamycin regimen in some of the women with an Enterococcus infection. The implications of these findings for the future selection of antibiotics for patients with severe obstetric-gynecologic infections are discussed.