HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by ZARATE, A. Articles by CANALES, E. S. Search for Related Content PubMed PubMed Citation Articles by ZARATE, A. Articles by CANALES, E. S.

Effect of Thyrotropin Releasing Hormone (TRH) on the Menstrual Cycle in Women

From the Hospital Gineco Obstetricia No. Uno, Instituto Mexicano del Seguro Social, Mexico, Veterans Administration Hospital, New Orleans, and Washington University, St. Louis, Missouri

Abstract

Thyrotropin releasing hormone (TRH) was given to 6 women for 8 consecutive days beginning between Days 8 and 9 of the menstrual cycle. Daily serum samples were obtained for radioimmunoassay for lutcinizing hormone (LH), follicle-stimulating hormone (FSH), and prolaclin (PRL) secretory response. Thyrotropin releasing hormone was ineffective in interfering with ovulation and failed to show significant effects on cycle lengths. Moreover, the length of the lutcal phase was not affected by TRH, as demonstrated by basal body temperature, endometrial biopsy, and pregnancdiol excretion. These results are in disagreement with recent findings in baboons receiving TRH. This study also demonstrated that TRH administration induces a prolactin secretory response which blocks neither the LH surge nor the ovarian responsiveness to endogenous gonadotropins women who menstruate normally.