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Maternal Serum Hormonal Changes in Hypertonic Saline-Induced Abortion

¹From the Pregnancy Research Branch, National Institute of Child Health, Department of Obstetrics and Gynecology, University of California, Davis, California
²From the Human Development, National Institutes of Health, Department of Obstetrics and Gynecology, University of California, Davis, California
³From the Department of Obstetrics and Gynecology at Ohio State University, Columbus, Ohio

Abstract

To examine how maternal hormone levels relate to hypertonic saline-induced abortion, peripheral serum levels of human chorionic gonadotropin (HCG), human chorionic somato-mammotropin (HCS), progesterone (P), estrone (SE₁) and 17ß-estradiol (SE₂) were determined at frequent intervals after saline injection in 6 patients. Levels of HCS, SE₁ and SE₂ decreased in 5 patients while HCG was unchanged and levels of P were variable. It is suggested that the hormonal changes reflect fetoplacental damage and are probably unrelated to the mechanism of labor induction.