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Clinical Diagnosis of Vaginal Adenosis

From the Department of Gynecology and Obstetrics, The Medical College of Wisconsin, Milwaukee, Wisconsin

Abstract

Sixty-three patients whose mothers took diethylstilbestrol in the first trimester of pregnancy were studied colposcopically. Vaginal adenosis was found in 91% of patients, and the remaining 9% of cases had extensive eversion of columnar epithelium on the ectocervix. Gross examination was negative in 71% of the cases of vaginal adenosis. Vaginal adenosis produced the same colposcopic pattern as columnar epithelium on the cervix. Confirmation of the origin of vaginal adenosis from the columnar epithelium in the cervix was documented by histochemical correlation of the terminal vascular network. This study demonstrated that colposcopy was an accurate method for the diagnosis of vaginal adenosis, particularly in cases which were not apparent by other methods.