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Obstetrics & Gynecology 1973;41:701-706
© 1973 by The American College of Obstetricians and Gynecologists
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Effect of Anticancer Drugs on Uterine Carcinogenesis

HIROYOSHI TAKAMIZAWA, MD and KISHO WONG, MD

From the Department of Obstetrics and Gynecology at the Chiba University School of Medicine, Chiba, Japan

Abstract

An assessment was made of the prophylactic effect of Endoxan and Bleomycin on 20-methylcholanthrene-induced cervical carcinoma in mice receiving the drugs from the early stage of experimental carcinogenesis. Marked inhibition of carcinomatous development and salient suppression of atypical epithelial proliferation were evident in animals treated with the anticancer chemotherapeutic agents. Administration of the drugs in early precancerous stage was observed to be more effective.






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Copyright © 1973 by the American College of Obstetricians and Gynecologists.