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In Vitro Responses of the Spermatozoa-Cervical Mucus System Treated with Prostaglandin (F₂)

From the Division of Gynecology and Obstetrics, Endocrine Section, Albert Einstein Medical Center, Northern Division, Philadelphia, Pa

Abstract

The effects or prostaglandin F₂ on the spermatozoa-cervical mucus system was evaluated clinically in vitro. A modification of the tube technic described by Kanatakc and Davajan was used to determine the effect of PGFM on the motility, penetration and drive of spermatozoa through treated mucus. The results show a significant increase in all of these characteristics when the pharmacologic and physiologic level (250 µµg/mt) of PGF₂ is used. The greatest effect in vitro was observed with cervical mucus obtained within 48 hours of probable ovulation.

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