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Obstetrics & Gynecology 1973;41:364-368
© 1973 by The American College of Obstetricians and Gynecologists
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Effects of Diazepam on Uteroplacental and Fetal Hemodynamics and Metabolism

M. MOFID, MD, C R BRINKMAN, III, MD and N S ASSALI, MD

From the Department of Obstetrics & Gynecology, University of California School of Medicine, Los Angeles, California 90024

Abstract

The effects of diazepam (Valium®) on utcro-placental and fetal circulation as well as oxygen consumption were investigated in near-term ewes. When injected into the mother in closes between 0.1 and 0.5 mg/kg, diazepam did not alter uteroplaccntat hemodynamics and oxygen transfer; doses greater than 0.5 mg/kg produced a slight fall in maternal arterial pressure and uteroplacental blood flow. Fetal hemodynamics and oxygen consumption were not altered by any of the doses administered to the mother. Administered intravenously to the fetus with intact umbilical circulation, in doses varying between 0.5 and 8.0 mg/kg, diazepam did not alter the fetal cardiovascular functions or oxygenution.






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