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Obstetrics & Gynecology 1973;41:337-342
© 1973 by The American College of Obstetricians and Gynecologists
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Human Amniotic Fluid Isoamylases

Functional Development of Fetal Pancreas and Salivary Glands

ROBERT O. WOLF, DDS and LYNN M. TAUSSIG, MD

From the Oral Medicine and Surgery Branch, National Institute of Dental Research and Pediatric Metabolism Branch, National Institute of Arthritis, Metabolic, and Digestive Diseases

Abstract

The source, production site and isoamylase patterns of amniotic fluid amylase have not previously been described. Samples of amniotic fluid from 21 pregnancies were obtained at various times during gestation. Other body fluids and tissue homogenates were studied. The isoamylases were separated by disc poly-acrylamidc gel electrophorcsis and identified by iodine development after incubating on a starch-agar film. Amniotic fluid amylase concentrations rise significantly during gestation; zymograms of amniotic fluid were nearly identical to those of neonatal urine, revealing distinct salivary and pancreatic components. Zymograms of homogenized placenta, liver and intestine were similar to adult scrum and different from amniotic fluid. The similarity between amniotic and neonatal urine zymograms is indicative of the fetal pancreas and salivary gland origin of amniotic fluid amylasc, with production as early as 16 to 18 weeks.






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