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Obstetrics & Gynecology 1973;41:259-264
© 1973 by The American College of Obstetricians and Gynecologists
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Intrauterine Contraceptive Device and Increased Serum Immunoglobulin Levels

DIETER W. GUMP, MD, PHILLIP B. MEAD, MD, ELIZABETH L. HORTON, BS, KATHLEEN R. LAMBORN, PhD and BEN R. FORSYTH, MD

From the University of Vermont, College of Medicine Burlington, Vt 05401

Abstract

Studies of 92 women with intrauterine contraceptive devices IUD's in place for 2 weeks to 6G months confirm an earlier report that serum IgG and IgM levels are significantly increased compared to levels for women without ITJDs. In this study the IgG rise occurred earlier than the IgM rise and was noticeahlc even in those women with the device in place less than 2 months. The IgM rise was more gradual and was not marked until the IUD had heen in use for over 1 year. No changes in serum IgA levels were seen. Limited studies to determine if mycoplasma or viral infection could be implicated in this immunoglobuliu rise were negative.






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