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Obstetrics & Gynecology 1973;41:129-136
© 1973 by The American College of Obstetricians and Gynecologists
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Megestrol Acetate in the Management of Advanced Endometrial Carcinoma

RAYMOND B. WAIT, MD, FACOG

From the Mead Johnson Research Center, Evansville, Ind 47721

Abstract

Megestrol acetate is an orally active progestin of the 17a-aceloxyprogesterone type. In a series of 130 patients with recurrent or melastatic endometrial carcinoma, 81 were treated with megestrol acetate alone for at least 2 months. Of this number, 32 patients (39.5%) showed objective responses to therapy. A like number failed to respond to megestrol acetate, while 17 (21%) showed a partial response. Those patients with slow-growing, well-differentiated tumors generally responded best. Side effects were mild and infrequent.






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Copyright © 1973 by the American College of Obstetricians and Gynecologists.