HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by MERKOW, L. P. Articles by PARDO, M. Search for Related Content PubMed PubMed Citation Articles by MERKOW, L. P. Articles by PARDO, M.

Human Ovarian Neoplasms, Light and Electron Microscopic Correlations

From the Division of Experimental Pathology at the William H. Singer Memorial Research Institute, Allegheny General Hospital and the Department of Pathology of the University of Pittsburgh Medical School, Magee-Women's Hospital, Pittsburgh, Pa.

Abstract

Two major types of Brenner cells were distinguished on the basis of their cytoplasmic tinctorial qualities. By light microscopy, nuclei of both light and dark cells often contained prominent grooves and nucleoli. The cytoplasm of many light cells contained granules in a juxtanuclear position. By electron microscopy, the nuclear grooves were found to represent invaginations of both the nuclear envelope and nucleoplasm, and cytoplasmic dense granules represented lysosomes. Prominent interdigitations of the plasmalemma or pseudovilli were found to be contiguous with ovoid clear spaces and desmosomes. A specific, larger dark Brenner cell displayed a large, central vacuole containing small vesicular elements and finely granular material. It appeared to correlate well with a large type of PAS-positive cell noted by light microscopy. The histogenesis of the Brenner tumor is discussed.