HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by BOUTSELLIS, J. G. Search for Related Content PubMed PubMed Citation Articles by BOUTSELLIS, J. G.

Intraepithelial Carcinoma of the Cervix Associated with Pregnancy

From the Department of Obstetrics and Gynecology at the Ohio State University College of Medicine, 410 West 10th Ave, Columbus, Ohio 43210.

Abstract

One hundred thirty-four patients with intraepithelial carcinoma associated with pregnancy were seen at University Hospital between 1940 and 1971. The typical patient was asymptomatic (78%), had a normal looking cervix (76%), yielded a Class III cytologic smear (70%) and was between 26 and 30 years of age. A definitive diagnosis was made by cold knife conization of a Schiller-stained cervix; the post cone complication rate was 20%. Punch biopsy of visible lesions yielded a diagnostic error of 22%. The incidence of residual tumor in the hysterectomy specimen was 3.5% in histologic Grade I lesions, 39.9% in Grade III lesions and higher in patients coned during the third trimester of pregnancy. The incidence of microinvasive carcinoma, which was almost exclusively limited to histologic Grade III lesions, was 8.9%. Vaginal delivery and subsequent simple hysterectomy is advocated for intraepithelial and microinvasive carcinoma. No deaths attributed to cervical neoplasia occurred among the 134 patients with intraepithelial or microinvasive carcinoma associated with pregnancy.