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Hyperparathyroidism During Pregnancy

From the Departments of Obstetrics and Gynecology, University of Cincinnati Medical Center and The Christ Hospital, Cincinnati, Ohio.

Abstract

Primary hyperparathyroidism during pregnancy has now been reported in 35 women; this incidence is less than expected by chance. Many hyperparathyroid women may not have been diagnosed as such. Screening by determining serum calcium concentration is valuable and may detect asymptomatic patients, but pregnancy lowers calcium concentrations making diagnosis more difficult. Detection is important because hyperparathyroidism is associated with premature labor, stillbirth and neonatal tetany, and the mother's kidneys may be progressively and irreversibly damaged. The only effective treatment for primary hyperparathyroidism is to remove the hyperfunctioning parathyroid tissue. Despite pregnancy, exploration of the neck should be considered at the time of diagnosis, and possible benefits weighed against risks for each individual.

This article has been cited by other articles:

				C. S. Kovacs and H. M. Kronenberg Maternal-Fetal Calcium and Bone Metabolism During Pregnancy, Puerperium, and Lactation Endocr. Rev., December 1, 1997; 18(6): 832 - 872. [Abstract] [Full Text]