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Relationship of Oral Contraceptives to Cervical Carcinogenesis

From the Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md 21205.

Abstract

A retrospective epidemiologic study was conducted to determine whether the risk of carcinoma in situ or squamous dysplasia of the uterine cervix was altered in women who used oral contraceptives. A contraceptive history, and answers to questions regarding other characteristics with which cervical carcinoma may be associated, were obtained from 324 women with cytologic smears suggestive of neoplasia, and from 302 controls selected to be representative of the population from which the cases were derived. The results lead to the conclusion that women who use oral contraceptives for an average of 20 months are not more likely to develop squamous dysplasia or carcinoma in situ within 2 1/2 to 3 years after initial use than are women who do not use oral contraceptives.

This article has been cited by other articles:

				E Stern, A. Forsythe, L Youkeles, and C. Coffelt Steroid contraceptive use and cervical dysplasia: increased risk of progression Science, June 24, 1977; 196(4297): 1460 - 1462. [Abstract] [PDF]