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Obstetrics & Gynecology 1972;40:466-472
© 1972 by The American College of Obstetricians and Gynecologists
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Gonadoblastoma in a True Hermaphrodite With 46,XY Genotype

I. JAMES PARK, MD, JOELLA C. PYEATTE, MD, HOWARD W. JONES, JR, MD, FACOG and J. DONALD WOODRUFF, MD, FACOG

From the Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Md 21205.

Abstract

Gonadoblastomas have been reported to arise in various types of dysgenetic gonads in patients with Turner's syndrome, pure gonadal dysgenesis, mixed gonadal dysgenesis or male hermaphroditism. With rare exception, such patients have been sex-chromatin negative. A gonadoblastoma has never been reported as arising in the gonad of a patient with true hermaphroditism. For this reason, such a case is reported. It is probably relevant that this particular true hermaphrodite was sex-chromatin negative with a 46,XY karyotype.






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