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Obstetrics & Gynecology 1972;40:391-393
© 1972 by The American College of Obstetricians and Gynecologists
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Pregnancy Outcome in Rats with Aortic Ligation

S. SYBULSKI, PHD, Y. OMAY, MD and G. B. MAUGHAN, MD, FACS, MRCOG

From the Hellenic Research Laboratory and the Department of Obstetrics and Gynaecology, Royal Victoria Hospital, Montreal, Quebec, Canada.

Abstract

The aorta, between the origins of the renal arteries, was ligated completely in Wistar virgin rats which were subsequently mated. Significantly fewer live fetuses were delivered per litter at days 21 and 22 of gestation than among nonligated controls. Also, oxygen utilization rates (QO3) in placental and fetal brain and liver tissue from aortic-ligated rats tended to be lower than in corresponding tissues from normal controls when incubated under in vitro conditions. However, the difference from the normal, in average QO3 values, was significant only in fetal liver.






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