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Obstetrics & Gynecology 1972;40:180-185
© 1972 by The American College of Obstetricians and Gynecologists
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Placental Transfer of Ethanol and Its Elimination at Term

RICHARD WALTMAN, MD, FACOG and EMELITA S. INIQUEZ, MD

From the Brooklyn-Cumberland Medical Center, 121 DeKalb Ave, Brooklyn, NY, 11201.

Abstract

Ethanol, administered intravenously to the mother at the time of delivery, traverses the placenta and, within 1 minute, is present in the bloodstream of the newborn. In 22 of 23 patients, serum ethanol levels in the umbilical vein and artery were consistently lower than or equal to those in maternal venous blood drawn simultaneously. After predelivery infusion, postpartum levels of maternal venous ethanol fell in a linear (zero) order or kinetics, with a half-life measured in 1 to 4 hours. The infants' Apgar scores or clinical course in the nursery were not affected adversely when ethanol was administered, in the dosage reported, either before or at the time of delivery. The induction of fetal hepatic as well as placental microsomal enzymes from the maternal ingestion of drugs during pregnancy is discussed.






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Copyright © 1972 by the American College of Obstetricians and Gynecologists.