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Plasma Progesterone Levels for Detection of Induced Ovulation

From the Academic Department of Obstetrics and Gynaecology, and The Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London, England.

Abstract

Plasma progesterone levels measured at weekly intervals in 65 women who were being treated with clomiphene or gonadotrophins for anovulatory infertility, proved useful for detecting ovulation in infertile women and for confirming the onset of pregnancy. After treatment with clomiphene mean plasma progesterone levels during ovulatory cycles were higher (10 to 50 mµmg/ml) than those present during spontaneous ovulation (10 to 20 mµg/ml). Patients were distributed into three groups according to frequency of menstruation before treatment. Evidence of ovulation after treatment with clomiphene was observed in patients from each group but occurred more frequently in patients with irregular cycles (27 of 28) than in those with oligomenorrhea (39 of 48) or amenorrhea (5 of 16). Plasma progesterone was measured by a competitive protein binding technic after purification by thin-layer chromatography.