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Obstetrics & Gynecology 1972;40:65-81
© 1972 by The American College of Obstetricians and Gynecologists
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Uterine and Cardiovascular Effects of Ritodrine in Premature Labor

JOSEPH BIENIARZ, MD, MARTIN MOTEW, MD and ANTONIO SCOMMEGNA, MD, FACOG

From the Section of Uterine Physiology, Department of Obstetrics and Gynecology, Michael Reese Hospital and Medical Center, and the Pritzker School of Medicine of the University of Chicago, Chicago, I11 60616.

Abstract

Ritodrine hydrochloride infused intravenously at increasing rates of 100 to 300 µg/min inhibited uterine contractility completely in 5 of 6 premature labors. Effective inhibition of the intensity of uterine contractions, which had been unresponsive to other treatments, makes ritodrine a valuable synergetic agent in the combined treatment of premature labor, when single agents fail. A moderate increase in heart rate and pulse pressure suggests an increased cardiac output and placental perfusion during treatment with ritodrine.






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Copyright © 1972 by the American College of Obstetricians and Gynecologists.