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PHENYLKETONURIA AND THE OBSTETRICIAN

From the Child Development Clinic, University of Iowa School of Medicine, Iowa City, Iowa 52240.

If a pregnant woman has an elevated blood phenylalanine level, it is likely that she will give birth to a microcephalic, small-for-dates baby with multiple congenital anomalies and future mental retardation. The elevated maternal phenylalanine has affected the fetus; after delivery the newborn's phenylalanine level will be normal. At present, only newborns are routinely screened for hyperphenylalaninemia. The obstetrician needs to be aware of the danger of undetected maternal hyperphenylalaninemia as well as maternal phenylketonuria. Blood phenylalanine should be monitored in all women at risk for pregnancy.

This article has been cited by other articles:

				K. F. Widaman and C. Azen Relation of Prenatal Phenylalanine Exposure to Infant and Childhood Cognitive Outcomes: Results From the International Maternal PKU Collaborative Study Pediatrics, December 1, 2003; 112(6): 1537 - 1543. [Abstract] [Full Text] [PDF]