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Obstetrics & Gynecology 1972;39:254-262
© 1972 by The American College of Obstetricians and Gynecologists
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Placental Transfer of Meperidine HC1

VAN R. JENKINS, II, MD, W. M. TALBERT, MD and P. V. DILTS, JR., MD

Departments of Obstetrics and Gynecology and Pathology, University of Kentucky College of Medicine, Lexington, Ky 40506.

Abstract

Meperidine HC1, injected intravenously (0.85–2.5 mg/kg) into the pregnant ewe, was transferred rapidly to the fetus. Fetal serum levels of meperidine were usually higher than but parallel to maternal levels. Both maternal and fetal meperidine serum levels peaked prior to 10 minutes postinjection, and umbilical venous levels were 11 µg% or less 50 minutes after injection. A gas-liquid chromatography method for meperidine analysis, using a 3–4 ml serum sample, is described and is considered advantageous because other alkaloids do not interfere.






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