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Obstetrics & Gynecology 1972;39:213-217
© 1972 by The American College of Obstetricians and Gynecologists
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Fibrinolytic Activity

Changes Induced With Oral Contraceptives

RODGER L. BICK, MD and WILLIAM B. THOMPSON, MD, FACOG

Kern County General Hospital, Bakersfield, Cal and University of California at Irvine-School of Medicine, Irvine, Calif.

Abstract

Studies of women using oral contraceptives have revealed an apparent hypercoagulable state; however, the effects of these agents on the fibrinolytic system have been little studied. Using a new fibrin plate method (Hyland) which quantitatively assays fibrinolytic potential or available plasminogen and active plasmin, 86% of 14 subjects had levels above normal; range: 123 to 167% of normal with an average of 143% of normal. It is suggested that an increase in fibrinolytic potential might be a compensatory protective mechanism in these patients, and this simple assay might help to detect women who are prone to thromboembolic problems while using these agents.






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Copyright © 1972 by the American College of Obstetricians and Gynecologists.